The Consortium

The AUTOSTEM consortium is a multi-disciplinary mix of engineers, regenerative medicine scientists and high-tech companies.

  • The project is led by Dr Mary Murphy of the National University of Ireland, Galway. 
  • The cell extraction device is being developed by Irish SME Crospon. Critically, Crospon has experience of designing, building and validating CE-approved devices in the past. This makes the learning curve (and risk) of the device less challenging.
  • The automated pipeline is built by the Fraunhofer Institute for Production Technology (IPT) in Aachen. It will benefit greatly from IPT’s experience in an earlier project (‘StemCellFactory’) where a similar pipeline was developed.
  • Cell isolation technology is provided by Irish SME Orbsen Therapeutics, who have unique capabilities and IP in the prospective isolation of stem cells from bone marrow and other cell types.
  • The bio-reactors will be provided by German SME ZellWerk (Berlin), and by the University of Aston, (Birmingham) in the UK. An important part of the project is to examine different options for large-scale cell production.
  • Sensor technology for controlling the cell culture environment is being developed by the Tyndall Institute, at University College Cork, in Ireland.
  • The cells produced by the pipeline will be tested and validated, to verify that they act as stem cells are expected to do, by the University of Genoa, Italy.
  • Risk assessment, health economics and process optimisation for the end-to-end project is supported by researchers from the UK’s Cell Therapy Catapult.
  • Administration, dissemination activity and exploitation planning are supported by Irish SME Pintail (Dublin).

 

Partner Organizations

The project brings together a multidisciplinary team

NUI GALWAY – The project is led by Dr Mary Murphy of the National University of Ireland, Galway, who have extensive cell therapy experience and GMP-accredited cell production facilities.
CROSPON – The cell extraction device is being developed by Irish SME Crospon. Crospon has experience of designing, building and validating CE-approved devices in the past.
ORBSEN – Cell isolation technology is provided by Irish SME Orbsen Therapeutics, who have unique capabilities and IP in the prospective isolation of stem cells.
ZELLWERK – Zellwerk, Berlin, contribute their unique ZRP bio-reactor, which combines unique ceramics with innovative control systems.
FRAUNHOFER IPT – The pipeline is built by the Fraunhofer IPT in Aachen. It will benefit from IPT’s experience in the project ‘StemCellFactory’.
ASTON UNIVERSITY – Aston University, Birmingham, are leading researchers in bioreactors, micro-carriers and large-scale cell production.
TYNDALL-UCC – Sensor technology for controlling the cell culture environment is being developed by the Tyndall Institute, at University College Cork
UNIVERSITY OF GENOA – The cells produced by the pipeline will be tested and validated in vivo by the University of Genoa, Italy
CATAPULT – Risk assessment, health economics and process optimisation are supported by the UK’s Cell Therapy Catapult.
PINTAIL – Administration, dissemination activity and exploitation planning are supported by Irish SME Pintail